Western Horse Tack Classifieds
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Perri’s Tack Hooks $1.6 This Tack Hook Will Slide Easily Over A Ledge In The Tackroom. Great Item To Take To Horse Shows. |
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Tough-1 Traveling Tack Rack $6.4 Clips over stall edge, horse trailer, tack trunk or use at home. Enameled tubular and bar steel construction. |
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Tack Trunk with Wheels $183.6 Roomy tack trunk can accommodate an English or Western Saddle. Tote tray included and wood handles. Comes with wheels attached. |
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Western Play Set with Horse & Cowboy Figure $5 Western Play Set with Horse & Cowboy Figure |
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Roma Portable Tack Rack $9 Roma Brand Quality. Products made from the finest materials with a complete line horse. Depend on Roma products for great quality and price. |
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Finishing Touch Finishing Touch Horse’S Behind Tack Pin Imitation Rhodium $3.95 HORSES REAR TACK PIN-IMITATION RHODIUM FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Finishing Touch Horse’S Behind Tack Pin Gold $3.95 HORSES REAR TACK PIN-GOLD FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Right Facing Walking Horse Tack Pin imitation Rhodium $3.95 RIGHT FACING WALKING HORSE TACK PIN-IMITATION RHODIUM FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Left Facing Walking Horse Tack Pin imitation Rhodium $3.95 LEFT FACING WALKING HORSE TACK PIN-IMITATION RHODIUM FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Right Facing Walking Horse Tack Pin Gold $3.95 RIGHT FACING WALKING HORSE TACK PIN-GOLD FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Left Facing Walking Horse Tack Pin Gold $3.95 LEFT FACING WALKING HORSE TACK PIN-GOLD FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Fancy Brass & Wood Tack Bracket $39.95 Fancy Brass and Wood Tack Holder. Smooth solid brass accented with hardwood trim. Will hold any style of English or Western bridles, halters or reins. 7W x 6H x 5D |
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Horse Sponge $2.1 Adorable Horse Sponge. This is a great addition to your tack box or a cute gift for a horse loving friend! |
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Horse Xing Western Caution Sign – Yellow $4.8 Horse Xing Western Caution SignColor: Yellow |
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Carr & Day & Martin Horse Tack Cleaning Sponge $1.9 Ideal For Applying Cleaners Or Conditioners To All Types Of LeatherA High Density, Hard Wearing, Quality SpongeWill Last Approximately 2-3 Months, Dependent On UseHandy Size: 10Cm X 7Cm |
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Tough-1 Bridle/Halter with 3 Prong Tack Rack $24.9 A great item for the horse shows! This Tough-1 Bridle/Halter carrier is constructed of a heavy denier Nylon. Features 2 pockets with quick grip closures, 3 hook tack rack, and an adjustable shoulder strap with clip. Measures 16 x 30. This unique bag will keep all of your good show tack clean and protected whether at the show in the barn or in the trailer. |
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SEDONA Printed Bridle/Halter Bag for Tack Rack $15.95 From the original SEDONA: Professional Riding Gear. A great item for the horse shows! For use with classic 3 or 4 prong tack racks. Features a zipper closure, Nylon shoulder strap and 2 pockets with Velcro closures to store bits or other accessories. Measures approx. 16 x 30. This unique bag will keep all of your good show tack clean and protected whether at the show in the barn or in the trailer. |
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SEDONA Bridle/Halter Bag for Tack Rack $18.95 From the original SEDONA: Professional Riding Gear. A great item for the horse shows! For use with classic 3 or 4 prong tack racks. Features a zipper closure, Nylon shoulder strap and 2 pockets with Velcro closures to store bits or other accessories. Measures approx. 16 x 30. This unique bag will keep all of your good show tack clean and protected whether at the show in the barn or in the trailer. |
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Carr & Day & Martin Horse Belvoir Tack Conditioning Spray – 500ml $15 Softens, Preserves And Shines Saddlery LeatherConditions, Protects And Supples Saddlery LeatherPure, Clear Quality Soap Formulated From Vegetable Oils, Including Coconut Oil And Glycerine For Regular UseUse After Step 1 Belvoir Tack CleanerApplicationSpray Evenly Onto Clean Leather And Gently Rub In With A Cloth Or Sponge. When Dry, Polish Using A Soft Dry Cloth. Not Suitable For Aniline Or Untreated Leather, Suede Or Nubuck. Test On A Hidden Area Before Use. Results Are Immediate500Ml Will Last Up To 3 Months, Dependent On UseKey Ingredients:Glycerine – Fills And Seals Any Pores In The Leather; Forms A Barrier Against Salt, Dirt, Grease And WaterCoconut OilSize: 500ml |
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Carr & Day & Martin Horse Belvoir Tack Conditioner Tray – 250g $8.5 Softens, Preserves And Shines Saddlery LeatherConditions, Protects And Supples Saddlery LeatherPure, Clear Quality Soap Formulated From Vegetable Oils, Including Coconut Oil And Glycerine For Regular Use, In A Re-Sealable Tray For Less Mess And Less WasteUse After Step 1 Belvoir Tack CleanerApplicationApply To Clean Leather And Gently Rub In With A Cloth Or Sponge. When Dry, Polish Using A Soft, Dry Cloth. Not Suitable For Aniline Or Untreated Leather, Suede Or Nubuck. Test On A Hidden Area Before Use. Results Are Immediate250Ml Will Last Up To 3 Months, Dependent On UseKey Ingredients:Glycerine – Fills And Seals Any Pores In The Leather; Forms A Barrier Against Salt, Dirt, Grease And WaterCoconut OilSize: 250g |
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Carr & Day & Martin Horse Belvoir Tack Conditioner Wipes – 15 Count $10.95 Convenient, Single-Use Impregnated Wipe Softens, Preserves And Shines SaddleryleatherConditions, Protects And Supples Saddlery LeatherPure, Clear Quality Soap Formulated From Vegetable Oils, Including Coconut Oil And Glycerine For Regular Use, In An Individual And Convenient, Single-Use Impregnated WipeUse After Step 1 Belvoir Tack CleanerApplicationRemove Wipe From Individual Sachet And Fully Unfold. Wipe Over Clean Leather, Using Both Sides Of The Wipe. Polish With A Soft, Dry Cloth. Not Suitable For Aniline Or Untreated Leather, Suede Or Nubuck. Test On A Hidden Area Before Use. Results Are Immediate.Key Ingredients:Glycerine – Fills And Seals Any Pores In The Leather; Forms A Barrier Against Salt, Dirt, Grease And WaterCoconut OilSize: 15 Count |
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Carr & Day & Martin Horse Belvoir Tack Cleaner Spray – 500ml $12.1 Effectively Cleans Leather, Removing Dirt, Grease And Sweat With Ease The New Step 1 In Tack Care – Leaving A Perfect Surface For The Immediate Application Of A Conditioning Soap Or OillContains A Blend Of Cleaning Agents To Remove Even Ingrained GreaseAnti-Fungal Formula Helps Prevent The Growth Of Mould And Mildew. Also Suitable To Hygenically Remove Existing Mould From Affected SaddleryThe Ph Neutral Formula Will Not Rot Stitching Or Over Dry The Leather ApplicationSpray Directly Onto Leather And Wipe Clean. For Ingrained Grease, Leave In Contact For 5 Minutes. If Mould Is Present, Make Sure Cloth Is Not Re-Used And Is Disposed Of, Away From Leather Items. Can Also Be Used On Synthetic Leather. Test On A Hidden Area Before Use. Results Are Immediate. 500Ml Will Last Up To 2 Months, Dependent On Use Key Ingredients:Cleaning AgentsSize: 500ml |
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Finishing Touch Finishing Touch Gen. Horse Head/Shoe Gold Tack Pin $11.95 HORSE HEAD IN SHOE TIE TACK-GOLD FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Paso Fino Tack Pin Gold $3.95 PASO FINO TACK PIN-GOLD FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Miniature Horse Western Saddle Pad $21.9 This classically designed saddle pad is sized just for the miniature horse. Features soft fleece underside, wear leathers at the appropriate places, and a fun southwest design. Measures approx. 19 x 19. The perfect pad to fit all of your mini’s western riding activities. Design may vary slightly but it is a Tan Southwestern design on each pad. |
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Texas Tack Pecos Wool Show Saddle Blanket $79.95 Texas Tack 100% Handwoven Saddle Blankets Texas Tack 100% Wool Handwoven Saddle Blankets. Authentic Designs – Popular Show Colors – Full 34 x 36 Show Size. Hand loomed with 100% wool, hand dyed show colors in traditional show blanket designs. These 100% wool saddle blankets measure a full 34 x 36, are thick to absorb shock and sweat, provide air circulation and evaporate sweat off the horse’s back. Variations – Handwoven patterns and colors may vary slightly from web photographs. Pecos Wool Show Blankets. Handwoven of 100% wool in Pecos design. Weight about 4-1/2 lbs. |
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Texas Tack Hudson Wool Show Saddle Blanket $61.95 Texas Tack 100% Handwoven Saddle Blankets Texas Tack 100% Wool Handwoven Saddle Blankets. Authentic Designs – Popular Show Colors – Full 34 x 36 Show Size. Hand loomed with 100% wool, hand dyed show colors in traditional show blanket designs. These 100% wool saddle blankets measure a full 34 x 36, are thick to absorb shock and sweat, provide air circulation and evaporate sweat off the horse’s back. Variations – Handwoven patterns and colors may vary slightly from web photographs. Hudson Wool Show Blankets. All wool heavyweight handwoven five color saddle blanket in pattern with wide and narrow stirpes that show under saddle skirt. Weight about 4-1/2 lbs. |
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Finishing Touch Magnetic Shamrock Tack Pin Gold $12.95 4-leaf clover magnetic tack pin w/green Swarovski crystal, green glitter epoxy, plated 14kgFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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ThinLine Western Felt Liner – Black $178.2 6mm Western Felt Liner with Ultra ThinLine, Protection for your horse without losing rider feel. Panels of 1/4 inch ThinLine are sewn on top with pockets to add shims for minor saddle fitting needs. Shims (sold separately) should be used only as needed.Plenty of Protection under the saddle for you and your horse but with only 6mm at your leg.Endorsed by Vets and Chiropractors for Equine Back HealthThe soft supple felt lies perfectly on horses with all back and wither types.Easy to trim for shorter saddles, use under your show pad.Made in the USA. Better Tack means better Horses.Color: Black |
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Finishing Touch Finishing Touch Horseshoe With Stones Tack Pin Gold $11.95 HORSE SHOE WITH STONE TACK PIN-GOLD FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Ultra ThinLine Western Felt Liner – Black $196.2 6mm Western Felt Liner with Ultra ThinLine, Protection for your horse without losing rider feel. Panels of Ultra ThinLine are sewn on top with pockets to add shims for minor saddle fitting needs. Shims (sold separately) should be used only as needed.Plenty of Protection under the saddle for you and your horse but with only 6mm at your leg.Endorsed by Vets and Chiropractors for Equine Back HealthThe soft supple felt lies perfectly on horses with all back and wither types.Easy to trim for shorter saddles, use under your show pad.Made in the USA. Better Tack means better Horses.Color: Black |
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Finishing Touch Saddlebred Magnetic Tack Pin Ant. Silver W Gold Horse $24.95 MAGNETIC NUMBER SIGN PINS WITH GOLD SADDLEBRED HORSE PLACED ON SILVER DISCFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Finishing Touch Horseshoe With Stones Tack Pin Silver $11.95 SILVER HORSESHOE TIE TACK WITH CRYSTALSFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Finishing Touch Concha With Stone Tack Pin Gold Carded $3.95 LARGE CONCHA WITH STONE TACK PIN-GOLD FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Paso Fino Tack Pin imitation Rhodium $3.95 PASO FINO TACK PIN-IMITATION RHODIUM FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Right Facing Arabian Head Tack Pin imitation Rhodium $3.95 RIGHT FACING ARABIAN HORSE HEAD TACK PIN-IMITATION RHODIUM FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Oval With Onyx With Hrs Head Crystal Tack Pin Gold $18.95 The artist used a 16×12 oval black onyx stone, surrounded by channel set Swarovski crystals and highlighted with a tiny horse head to create this lovely tack/lapel pin. It is beautifully polished and plate 14kg.Finishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Right Facing Saddlebred Tack Pin Gold $3.95 RIGHT FACING SADDLEBERD HORSE TACK PIN-GOLD FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Left Facing Fluffy Tail Tack Pin imitation Rhodium $3.95 LEFT FACING REARING FLUFFY TAIL HORSE TACK PIN-IMITATION RHODIUM FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Right Facing Saddlebred Tack Pin imitation Rhodium $3.95 RIGHT FACING SADDLEBRED HORSE TACK PIN-GOLD FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Texas Tack Congress Pattern Wool Show Saddle Blanket $69.95 Texas Tack 100% Handwoven Saddle Blankets Texas Tack 100% Wool Handwoven Saddle Blankets. Authentic Designs – Popular Show Colors – Full 34 x 36 Show Size. Hand loomed with 100% wool, hand dyed show colors in traditional show blanket designs. These 100% wool saddle blankets measure a full 34 x 36, are thick to absorb shock and sweat, provide air circulation and evaporate sweat off the horse’s back. Variations – Handwoven patterns and colors may vary slightly from web photographs. Congress Wool Show Blankets. All wool heavyweight handwoven saddle blanket in Congress show pattern. Weight about 4-1/2 lbs. |
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Finishing Touch Finishing Touch Small Concha With Stone Tack Pin Gold $3.95 Assortment of Gold and Imitation Rhodium Number Sign Tack pinsFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Finishing Touch Large Concha Tack Pin Imitation Rhodium $3.95 Assortment of Gold and Imitation Rhodium Number Sign Tack pinsFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Finishing Touch Blue Ribbon Tack Pin Imitation Rhodium $3.95 Assortment of Gold and Imitation Rhodium Number Sign Tack pinsFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Finishing Touch Small Concha Tack Pin Imitation Rhodium $3.95 Assortment of Gold and Imitation Rhodium Number Sign Tack pinsFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Finishing Touch Double Horseshoe Tack Pin Gold Carded $3.95 Assortment of Gold and Imitation Rhodium Number Sign Tack pinsFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Finishing Touch Blue Ribbon Tack Pin Gold $3.95 Assortment of Gold and Imitation Rhodium Number Sign Tack pinsFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Finishing Touch Small Concha Tack Pin Gold $3.95 Assortment of Gold and Imitation Rhodium Number Sign Tack pinsFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Finishing Touch Large Concha Tack Pin Gold $3.95 Assortment of Gold and Imitation Rhodium Number Sign Tack pinsFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Left Facing Jumper Tack Pin imitation Rhodium $4.95 Left facing jumper tack pin faux rhodiumFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Left Facing Saddlebred With Rider Tack Pin Gold $3.95 LEFT FACING SADDLEBRED RIDER TACK PIN-GOLD FINISHFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Finishing Touch Magnetic Shamrock Tack Pin Imitation Rhodium $12.95 4-leaf clover magnetic tack pin w/green Swarovski crystal, green glitter epoxy, non-tarnish imitation rhodiumFinishing touch takes a great deal of pride in offering a high-quality product at a low price, and they stand behind their products. Finishing Touch is a 34-year-old Lexington Kentucky corporation located in the heart of Horse country and Horse Jewelry is their specialty. Finishing Touch Jewelry is all costume jewelry and is plated in either durable karat gold or imitation rhodium (gives a nice silver finish without the problem of tarnishing) over white metal or brass. Many items are manufactured right in Nicholasville, KY. Jewelry from The Finishing Touch of Kentucky withstands the test of time when cared for properly. |
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Effect of Shugan Jianpi Granule
Effect of Shugan Jianpi Granule on Gut Mucosal Serotonin-positive Cells in Patients with Irritable Bowe Syndrome of Stagnated Gan-qi Attacking Pi Syndrome Type
WANG Zai-jian l, LI Hui-xia 2, WANG Jing-hua 1, and ZHANG Fan 1
ABSTRACT Objective: To evaluate the effect of Shugan Jianpi Granule , SJG) on the number of gut mucosal serotonin-positive cells (5-HT+C) in patients with irritable bowel syndrome (IBS) of stagnated Gan-qi attacking Pi (SGAP) syndrome type. Methods: Twenty-four patients were randomized equally into three groups. All were treated with the basic conventional treatment by cognition-behavior therapy with assistance of lactein 3 tablets thrice a day. Additionally, 24 g of SJG was given three times a day to group A, and the same dosage of SJG and Smecta 15 g thrice a day was given to group B, while no additional treatment was given to the control group. The number of 5-HT+C was measured respectively before and two weeks after treatment by immunohistochemical method. Results: The number of 5-HT+C decreased after treatment in all the three groups (P<0.05), but the decrement was more significant in the two test groups than in the control group (P<0.05 and P<0.01, respectively), while comparison of 5-HT+C between the two test groups showed insignificant difference (P>0.05). Conclusion: SJG can reduce the number of 5-HT+C in IBS patients of SGAP syndrome type, and its effect is enhanced when used in combination with Smecta.
KEY WORDS Shugan Jianpi Granule, irritable bowel syndrome, serotonin
Irritable bowel syndrome (IBS) is a clinical syndrome involving digestive functional changes without intestinal constitutive and biochemical abnormalities; that is, no pathologically based organic change could be found. Researches showed that the occurrence of IBS of the diarrhea type (IBS-D) is closely related with the abnormal secretion of serotonin, an intestinal neural transmitter related with mental psychic factor(1).
The Chinese drug Shugan Jianpi Granule SJG) possesses the actions of stretching Gan ,strengthening Pi regulating qi and activating blood circulation, and is commonly used for the treatment of diarrhea, abdominal pain, etc., caused by Gan stagnation, Pi deficiency and qi-blood stasis, and IBS of stagnated Gan-qi attacking Pi (SGAP) syndrome type is one of the indications of SJG.
This study was a controlled trial designed for evaluating the effect of SJG on the number of gut mucosal serotonin-positive cells (5-HT+C) in IBS patients of SGAP syndrome type by way of observing the change in the number of 5-HT+C before and after SJG treatment.
METHODS
Diagnosis Standard and Clinical Materials
Patients with diagnosis of IBS-D up to the Rome ? standard(2), and with TCM syndrome of SGAP matching the standard in the integrative medical diagnosis and treatment program (draft)(3) were selected.
All the 24 patients enrolled were outpatients visiting the clinics of digestive medicine, the Third Hospital Affiliated to Beijing University of Chinese Medicine from March 2007 to August 2007. They were distributed into 3 groups equally according to the sequence of their visit. The 8 patients in group A were 4 males and 4 females, aged between 21-45 years, 31.8 ± 15.6 years on average, with the
disease course of 3-19 months, 13.1 ±8.7 months on average; the 8 patients in group B were 3 males and 5 females, aged between 28-39 years, 35.2±16.4 years on average, with the disease course of 4-28 months, 15.3± 12.7 months on average; the 8 patients in the control group were 4 males and 4 females, 18-46 years old, with the mean of 32.2±14.8 years. The three groups were insignificantly different in general conditions like age, sex, and course of disease (P>0.05).
Treatment
Treatment was implemented by an appointed specialist trained by the neurological department. The basic therapy given to all patients in the three groups included mainly recognition-behavior treatment, with the auxiliary measures of diet-guidance and oral administration of lactein tablet, three times a day, 3 tablets each time.
Additionally, for patients in group A, SJG was given three times a day, 24 g each time, which is a Chinese medicine consisting of nutgrass galingale rhizome, white atractylodes rhizome, tangerine peel, notoginseng, etc., made by the pharmacy department of Beijing University of Chinese Medicine; for patients in group B, besides the SJG given to group A, 15 g of Smecta (a product of Bofu-Yipusheng Pharmaceutical Co., Ltd., batch No. H20000690) thrice a day was also given; no additional treatment was given to the patients in the control group. The observation period lasted over 2 weeks for all the three groups.
Indexes and Methods of Observation
Sample Collection
Colonoscopic examination on fasting condition was performed in all patients before and after treatment to take 2-3 pieces of biopsy from the sigmoid-rectal conjuncture, and then the sample tissues were fixed by 4% formaldehyde, gradient alcohol dehydrated, dimethylbenzene hyalinized and paraffin embedded.
Immunohistochemical Stain
The paraffin embedded tissue was sectioned into 5 µ m successive slides, dewaxed in routine, managed with 3% H202 to block the endogenic peroxidase, rinsed with PBS, and incubated with 10% goat serum under 37? for 15 min. With the serum discarded, the sample was co-incubated with rabbit anti-human 5-HT multi-colony antibody (primary antibody, product of Zhongshan Company, China) under 37? for 1 h and under 4? overnight, then incubated in turn with 25-50 µg/mL biotin labeled secondary antibody (SP-9000, product of Zhongshan Company, China) under 30? for 40 min; followed by incubation with 25-50 µg/mL horse radish peroxidase labeled streptavidin, and after PBS rinsing, colored by 0.05% diaminobenzidine, terminated with water in time, hematoxylin stained, then hyalinized to make a neutral resin slide.
The blank negative control was made in the same procedure but PBS was used instead of primary antibody; the tissue of the appendix was used as the positive control.
5-HT+C Count
The stained 5-HT+C presented principally in cell plasma, showed itself to be brown-yellow, yellow or jasmine, which indicated the different degrees of positive responses such as strong positive, positive and weak positive respectively. Cells failing to be colored were regarded as serotonin negative cells.
The number of 5-HT+C in 5 high power visual fields (upper, lower, left, right, and middle) in each slide was counted with an Olympus laser cofocusing scanning microscope type FV500, and their sum was brought into analysis.
Statistical Analysis
Paired t-test was used for comparison of data before and after treatment in the same group, variance analysis for difference between groups, and X2 test for classified variable like age and sex. All were managed by SAS 6.12 software.
RESULTS
Changes in Immunohistochemical Figures
The positive colored site was mainly located at the plasma of glandular cells. Before treatment, 0-3 5-HT+C in each glandule with a few infiltration of lymphocytes and neutrophils around it could be seen in all samples of the three groups. After
treatment, the 5-HT+C and infiltration were reduced in all groups, but the reduction in group B was more significant, and the lymphocytes and neutrophils around the glandular organ were reduced significantly (Figure 1).
Comparison of the Number of 5-HT+C
The number of 5-HT+C in the three groups were different insignificantly before treatment (P>0.05), but it reduced in all groups after treatment, showing significant difference as compared with those before treatment (P<0.05). Inter-group comparison showed that significant difference was only shown in the
comparison between the control group and the two test groups (P<0.05, P<0.01), while insignificance was shown between the two test groups (P>0.05). However, the decrease in group B seemed rather more evident (Table 1).
DISCUSSION
IBS is one of the functional intestinal diseases often encountered. As a neuro-transmitter closely related with mental psychic factor, the action of 5-HT in IBS has been studied deeply. On the account that it is the main inflammatory mediator for intestinal secretion and abnormal feeling, many drugs for IBS treatment targeted on various subtypes of 5-HT receptors have been synthesized and effectively applied in clinical practice, among which, the 5-HT3 receptor antagonist displays a more prominent effect for IBS-D(1).
Through literature review, Gershon, et al(4) held that various degrees of 5-HT signal transmission abnormality exist in all IBS patients and other intestinal dysfunction patients, which might be the pathogenetic basis for IBS. Our previous study showed that gut mucosal concentration of 5-HT and its related neuro-endocrinal cells, as intestinal pheochromocyte, play an important role in the pathogenesis of IBS(5,6).
Traditional Chinese medicine (TCM) holds that IBS-D belongs to the categories of “loosing bowel”, “abdominal pain” and “melancholia”. For its pathogenesis, ancient doctors suggested the theory of “Gan-disease passing to Pi” in such ancient medical books as “Nan-jing and “Jingui Yaolue “; while recent reports indicated that the often seen TCM syndrome of IBS-D is stagnated Gan-qi attacking Pi, and other syndromes would always develop from it(7); Gan and Pi are acting and impacting mutually in the pathological process. The transporting and transforming function of Pi depends on the catharsis of Gan, its hyperfunction or hypofunction could induce the dysfunction of Pi to form the pathological basis of IBS-D.
SJG is a pure Chinese herbal compound medicine made on the basis of experiences accumulated for many years, which consists of ten odd kinds of Chinese drugs, such as nutgrass galingale rhizome, white atractylodes rhizome, tangerine peel and notoginseng, ect. SJG has the effects of smoothening Gan, strengthening Pi, regulating qi and activating blood circulation, and is applied in clinical practice for the treatment of diarrhea, abdominal pain and distention, poor appetite, etc. Experimental studies showed that SJG can regulate the concentration of mediators of inflammation of tissues in the animal model of ulcerative colitis to inhibit the inflammation of the intestinal tract(8); and compared with the Western medicine, the pure Chinese preparation has a better efficacy in treating patients with IBS-D, with fewer adverse reactions found(9).
On the basis of the syndrome differentiation criteria suggested by Chen ZS, et al(3), IBS patients of SGAP type matching the Rome ? diagnostic standard of diarrhea type were enrolled in this study. The results showed that before treatment, the numbers of 5-HT+C in the three groups were not different significantly. After treatment, although the number decreased in all the three groups, the decrement in the two test groups was more statistically significant than that in the control group, while the difference between the two test groups was insignificant. Accordingly, it was deduced that SJG possibly impacts on the genesis of IBS-D, but it is not the only influencing factor. SJG possibly plays its action through 5-HT+C, the vital endocrinal cell in 5-HT signal transmitting path, and the combining of SJG with Smecta might be cooperative and could enhance the effect on the path.
Besides, the number of 5-HT+C also decreased significantly in the control group, in which patients were treated with simple cognition-behavior therapy and diet-control, which further illustrated that the influencing factors on the gut mucosal 5-HT signal transmitting path might be multiple. This result coincides with the outcome of the authors’ previous study(6). Since it has been reported that the intestinal content of 5-HT in the fasting condition is different from that of postprandial(10), to avoid the influence of errors on the results, all the sampled biopsy for the test in this study were obtained in fasting condition.
All problems concerning changes of other cytokines and chemical mediators of gut mucosal 5-HT signal transmitting path in IBS patients, and molecular mechanisms that could affect the number of 5-HT+C remain to be further studied.
In sum, SJG, as a Chinese composite preparation for treatment of IBS patients of SGAP type or diarrhea type, might have an effect on the intestinal neuro-endocrinal network partly by way of influencing the number of gut mucosal 5-HT+C, thus realizing its clinical effect on patients. Besides, when SJG is used in combination with conventional recognition-behavior therapy and symptomatic treatment of Western medicine, it shows an apparent synergistic action on 5-HT+C.
REFERENCES
1. Costedio MM, Hyman N, Mawe GM. Serotonin and its role in colonic function and in gastrointestinal disorders. Dis Colon Rectum 2007; 50:376-388.
2. Drossman DA. The functional gastrointestinal disorders and the Rome ? process. Gastroenterology.2006; 130:1377-13 90.
3. Chen ZS, Zhang WD, Wei BH, et al. Schedule for diagnosis and treatment for irritable bowel syndrome with integrative Chinese and Western medicine (Draft). Chin J Integr Tradit West Med (Chin) 2005;25(3):282-284.
4. Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007; 132:397-414.
5. Wang ZJ, Ouyang Q, Zou YG, et al. Comparison of mucosal serotonin content in patients with ulcerative colitis and irritable bowel syndrome. Chin J Intl Med (Chin) 2005;44(11 ):851-852.
6. Wang Z J, Ouyang Q, Wei B, et al. Alteration of intestinal mast cells in cases with overlap syndrome inside ulcerative colitis and irritable bowel syndrome. J Clin Intl Med (Chin) 2005;22(10):674-677.
7. Han MH, Chen TQ. Exploration on evolvement rule and syndrome differentiation of diarrea-predominant irritable bowel syndrome. Guangming J Tradit Chin Med (Chin) 2007;22(3):35-36.
8. Qin ZS, Wang Y, Zhao Y, et al. Effect of Shugan Jianpi Granule on VIP and IL-10 in rats with ulcerative colitis. Jilin J Tradit Chin Med (Chin) 2007;27(3):48-50.
9. Tao Y, Chen DM, Dong MX, et al. The clinical study on Shugan Decoction in treating diarrhea-predominant irritable bowel syndrome. Chin Arch Tradit Chin Med (Chin) 2007;25(10):2190-2193.
10. Atkinson W, Lockhart S, Whorwell P J, et al. Altered 5-hydroxytryptamine signaling in patients with constipation and diarrhea-predominant irritable bowel syndrome. Gastroenterology 2006; 130:34-43.
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